Opportunity Information: Apply for HT942526RTRPIIRA
The FY26 DoD Reconstructive Transplant Research Program (RTRP) Investigator-Initiated Research Award is a Defense Health Agency funding opportunity (HT942526RTRPIIRA) designed to support investigator-driven studies that can meaningfully advance the science and practice of reconstructive transplantation. The program is looking for research that can plausibly improve patient care and/or quality of life in the reconstructive transplant space, with a clear expectation that the work is grounded in a strong scientific rationale and has practical, military-relevant utility. A key constraint is that this mechanism does not fund clinical trials, so proposed work needs to fit outside a clinical trial framework even if it involves human participants or human-derived materials.
In terms of what kinds of projects fit, the scope is intentionally broad across the research pipeline. Applications can range from basic research through translational efforts, including preclinical studies in animal models as well as clinical research that uses human subjects or human anatomical substances. In other words, the program is open to studies that build foundational knowledge, test mechanisms, validate targets, or move promising approaches closer to application, as long as the study design remains research-focused rather than a clinical trial.
The opportunity places heavy emphasis on rigorous study design and feasibility. Proposals are expected to be built for reproducibility and to have a credible path toward translation, meaning the methods, controls, and experimental structure should be robust and defensible. Applicants are expected to include a strong statistical plan, and power analysis is specifically called out as important, signaling that reviewers will scrutinize whether the sample size, endpoints, and analysis strategy can realistically answer the stated questions.
Impact is another central review theme. The program wants projects where the results could create either near-term or longer-term value for the reconstructive transplant field and/or the patient community. Applicants also need to align their work to at least one of the FY26 RTRP Focus Areas (not listed in the provided text), so a competitive application would clearly map aims and outcomes to one or more of those priorities and explain why that alignment matters.
Unlike some early-stage mechanisms, this award requires supporting evidence. Applicants must include preliminary and/or published data relevant to reconstructive transplantation that directly supports the rationale for the proposed research. That requirement implies the program is looking for proposals that are more than exploratory concepts and that can demonstrate readiness, technical credibility, and a reason to believe the approach will yield interpretable results.
Military relevance is mandatory. Projects must be responsive to the health care needs of military Service Members and/or Veterans recovering from traumatic injury, and may also address needs affecting their family members, caregivers, or clinicians, while still benefiting the general public. Collaboration with military researchers and clinicians is encouraged but not required, which leaves room for civilian-led teams, but it also suggests that proposals may be stronger if they show awareness of real-world military clinical constraints and care pathways.
Administratively, this is a discretionary grant opportunity in the Science and Technology and other Research and Development category (CFDA 12.420) managed by the Defense Health Agency Contracting Activity (DHACA). Eligibility is listed as unrestricted, indicating broad applicant eligibility rather than being limited to a narrow set of institution types. The opportunity was created on 2026-08-26, with an original closing date of 2026-11-04. The listing anticipates 8 awards, while the award ceiling is not specified in the provided source text.Apply for HT942526RTRPIIRA
- The Defense Health Agency Contracting Activity - DHACA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoW Reconstructive Transplant, Investigator-Initiated Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on 2026-08-26.
- Applicants must submit their applications by 2026-11-04. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 8 candidate(s).
- Eligible applicants include: Unrestricted.
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Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is the FY26 DoD Reconstructive Transplant Research Program (RTRP) Investigator-Initiated Research Award, a Defense Health Agency funding opportunity (HT942526RTRPIIRA) supporting investigator-driven research intended to advance the science and practice of reconstructive transplantation.
Who is the funding agency managing this opportunity?
The opportunity is managed by the Defense Health Agency Contracting Activity (DHACA) under the Defense Health Agency.
What is the main purpose of the Investigator-Initiated Research Award?
The award supports studies that can meaningfully advance reconstructive transplantation and plausibly improve patient care and/or quality of life. Proposed work is expected to be grounded in a strong scientific rationale and to have practical, military-relevant utility.
Is military relevance required?
Yes. Military relevance is mandatory. Projects must be responsive to the health care needs of military Service Members and/or Veterans recovering from traumatic injury. Projects may also address needs affecting family members, caregivers, or clinicians, while still benefiting the general public.
Are collaborations with military researchers or clinicians required?
No. Collaboration with military researchers and clinicians is encouraged but not required. Civilian-led teams may apply, and proposals may be stronger when they demonstrate awareness of military clinical constraints and care pathways.
What types of research are in scope?
The scope is broad across the research pipeline. Applications may include basic research, translational research, and preclinical studies in animal models, as well as clinical research that uses human subjects or human anatomical substances, as long as the design remains research-focused and is not a clinical trial.
Are clinical trials allowed under this award?
No. This mechanism does not fund clinical trials. Proposed work must fit outside a clinical trial framework, even if it involves human participants or human-derived materials.
Can projects involve human subjects?
Yes. The program allows clinical research using human subjects, provided the work is not designed as a clinical trial.
Can projects use human anatomical substances or human-derived materials?
Yes. The program allows research using human anatomical substances or human-derived materials, provided the overall study design is not a clinical trial.
Can projects include animal model studies?
Yes. Preclinical studies in animal models are included within the broad scope of this opportunity.
What does the program emphasize about study design?
The opportunity places heavy emphasis on rigorous study design, feasibility, and reproducibility. Proposals are expected to use robust and defensible methods, controls, and experimental structure, with a credible path toward translation.
Is a statistical plan required?
Yes. Applicants are expected to include a strong statistical plan.
Is a power analysis specifically expected?
Yes. Power analysis is specifically called out as important, indicating that reviewers are likely to scrutinize whether sample size, endpoints, and analysis strategy can realistically answer the stated research questions.
How is impact described for this award?
Impact is a central theme. The program seeks projects whose results could create near-term and/or longer-term value for the reconstructive transplant field and/or the patient community.
Do applications need to align with specific focus areas?
Yes. Applicants need to align their work to at least one of the FY26 RTRP Focus Areas. (The specific focus areas are not listed in the provided information.)
Is preliminary data required?
Yes. Unlike purely exploratory mechanisms, this award requires supporting evidence. Applicants must include preliminary and/or published data relevant to reconstructive transplantation that directly supports the rationale for the proposed research.
What does the preliminary/published data need to support?
The supporting evidence must be relevant to reconstructive transplantation and must directly support the scientific rationale for the proposed work, demonstrating readiness, technical credibility, and a reason to expect interpretable results.
What is the assistance listing type and category for this opportunity?
This is a discretionary grant opportunity in the Science and Technology and other Research and Development category.
What is the CFDA number listed for this opportunity?
The CFDA number provided is 12.420.
Who is eligible to apply?
Eligibility is listed as unrestricted, indicating broad applicant eligibility rather than being limited to a narrow set of institution types.
When was this opportunity created?
The listing was created on 2026-08-26.
What is the application closing date?
The original closing date is 2026-11-04.
How many awards are anticipated?
The listing anticipates 8 awards.
Is the maximum award amount (ceiling) provided?
No. The award ceiling is not specified in the provided information.
What is the identifying code for the funding opportunity?
The opportunity is identified as HT942526RTRPIIRA.
What kinds of outcomes is the program hoping to enable?
The program is looking for research that can plausibly improve patient care and/or quality of life in reconstructive transplantation, with practical utility and relevance to military health needs.
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