Opportunity Information: Apply for PA 17 298

The National Institutes of Health (NIH) funding opportunity titled "Integration of Individual Residential Histories into Cancer Research (R01)" (Funding Opportunity Number: PA 17 298) is a discretionary grant program designed to push cancer research beyond single point-in-time location measures by incorporating detailed, person-level residential histories. The core idea is that where someone lives across their life course can shape exposures and conditions that influence both the causes of cancer (etiology) and what happens after diagnosis (outcomes). This announcement specifically emphasizes substantive, hypothesis-driven research that uses residential history data to better understand cancer risk, progression, survivorship, and disparities, while also encouraging investigators to build and apply more sophisticated analytic approaches that can handle the complexity of time-varying places, exposures, and population movement.

The FOA is centered on two linked aims: first, supporting research that directly tests how changing residential contexts relate to cancer development and outcomes; and second, encouraging the development or refinement of complex analytical strategies that make those investigations possible and credible. In practice, this signals interest in studies that can connect address histories to environmental, social, policy, and health care-related contextual data over time, and then analyze those connections using methods that properly account for mobility, timing, duration, latency periods, and cumulative exposure patterns. The R01 mechanism indicates this opportunity is intended for full-scale research projects rather than small pilots, with the expectation of rigorous design, strong methodological justification, and clear potential to advance cancer epidemiology and population sciences.

A wide range of U.S.-based organizations can apply. Eligible applicants include state, county, city or township governments, and special district governments, as well as independent school districts. Academic institutions are eligible across categories, including public and state-controlled institutions of higher education and private institutions of higher education. Tribal participation is supported through eligibility for federally recognized Native American tribal governments, and also Native American tribal organizations and tribal governments that are not federally recognized. Housing-related public entities may apply, including public housing authorities and Indian housing authorities, which is relevant given the residential-history focus. The FOA also allows nonprofit organizations both with and without 501(c)(3) status, and it permits for-profit organizations (other than small businesses) as well as small businesses. Beyond those standard categories, the announcement explicitly highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal government agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. This breadth reflects an intention to support research capacity across many institutional settings, including those serving communities that may be disproportionately affected by cancer burdens and place-based inequities.

At the same time, the FOA sets clear restrictions on foreign involvement. Non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, are not eligible to apply. In addition, non-domestic components of U.S. organizations are not eligible to apply. The announcement further states that foreign components, as defined in the NIH Grants Policy Statement, are not allowed. In other words, the work must be grounded in eligible U.S.-based applicant organizations without foreign components under NIH definitions, reinforcing the domestic scope of the research supported through this opportunity.

From an administrative standpoint, this is an NIH grant under the health-related funding activity category (Education, Health) and is associated with CFDA number 93.393. The FOA was created on June 22, 2017, and the original closing date listed in the source information is September 7, 2020. The listing does not provide an award ceiling or expected number of awards in the provided fields, which typically means applicants would need to consult the full FOA and NIH institute-specific guidance for budget expectations, paylines, and anticipated funding levels. Overall, the opportunity is aimed at improving how cancer researchers incorporate the lived geography of individuals over time, recognizing that residential mobility and long-term neighborhood and environmental contexts can be central to understanding cancer risk, survival, and inequities in outcomes.

  • The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Integration of Individual Residential Histories into Cancer Research (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393.
  • This funding opportunity was created on 2017-06-22.
  • Applicants must submit their applications by 2020-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)

What is the name of this NIH funding opportunity?

The opportunity is titled "Integration of Individual Residential Histories into Cancer Research (R01)."

What is the Funding Opportunity Number (FON)?

The Funding Opportunity Number is PA 17 298.

What kind of grant mechanism is used?

This opportunity uses the NIH R01 mechanism, which is intended for full-scale research projects rather than small pilot studies.

What is the main purpose of this FOA?

The purpose is to advance cancer research beyond single point-in-time location measures by incorporating detailed, person-level residential histories to study how places lived over the life course relate to cancer causes (etiology) and outcomes after diagnosis.

Why does NIH emphasize individual residential histories for cancer research?

The FOA is based on the idea that where a person lives across their life course can shape exposures and conditions that influence cancer risk, cancer progression, survivorship, and disparities in outcomes.

What types of research does this FOA emphasize?

It emphasizes substantive, hypothesis-driven research that uses residential history data to better understand cancer risk, progression, survivorship, and disparities.

What are the two linked aims of the FOA?

The FOA centers on (1) supporting research that directly tests how changing residential contexts relate to cancer development and outcomes, and (2) encouraging the development or refinement of complex analytical strategies needed to conduct those investigations credibly.

What does "moving beyond single point-in-time location measures" mean in practice?

It means studying more than one address or one time period by using full address histories over time, so analyses can reflect mobility, timing, duration in places, latency periods, and cumulative exposure patterns.

What kinds of contextual data may be linked to address histories in these projects?

The FOA signals interest in connecting address histories to environmental, social, policy, and health care-related contextual data over time.

What kinds of analytic issues does NIH expect applicants to handle?

The FOA highlights the need for analytic approaches that account for time-varying places and exposures, population movement, timing and duration of residence, latency periods, and cumulative exposure patterns.

Is this FOA focused only on cancer risk, or also on outcomes after diagnosis?

It includes both: research on cancer causes (etiology) and what happens after diagnosis (outcomes), including progression and survivorship.

Does the FOA mention cancer disparities?

Yes. It explicitly notes interest in using residential histories to better understand cancer disparities and inequities in outcomes.

Who is eligible to apply (in general terms)?

A wide range of U.S.-based organizations are eligible, including government entities, academic institutions, nonprofits, for-profits (other than small businesses), and small businesses, along with several explicitly named institution types and community-based entities.

Which government entities are eligible applicants?

Eligible government applicants include state governments, county governments, city or township governments, special district governments, and independent school districts. Eligible federal government agencies are also listed as eligible.

Are academic institutions eligible?

Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.

Are Tribal governments and Tribal organizations eligible?

Yes. Eligibility includes federally recognized Native American tribal governments, Native American tribal organizations, and tribal governments that are not federally recognized.

Are housing-related public entities eligible to apply?

Yes. The FOA includes public housing authorities and Indian housing authorities among eligible applicant types.

Are nonprofits eligible, including those without 501(c)(3) status?

Yes. Nonprofit organizations with or without 501(c)(3) status are included as eligible applicants.

Are for-profit organizations eligible?

Yes. For-profit organizations (other than small businesses) are permitted, and small businesses are also listed as eligible.

Are faith-based and community-based organizations eligible?

Yes. Faith-based or community-based organizations are explicitly highlighted among eligible applicant types.

Are U.S. territories or possessions eligible?

Yes. U.S. territories or possessions are listed among the eligible applicant types.

Which minority-serving and other specifically named institution types are highlighted as eligible?

The FOA explicitly highlights Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), regional organizations, and other eligible categories described in the listing.

Are foreign organizations eligible to apply?

No. Non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, are not eligible to apply.

Can a U.S. organization apply if part of the work will be conducted outside the United States?

No. Non-domestic components of U.S. organizations are not eligible to apply, and foreign components (as defined in the NIH Grants Policy Statement) are not allowed.

Does this FOA allow foreign components under NIH definitions?

No. The listing states that foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

What is the funding activity category associated with this opportunity?

The opportunity is associated with a health-related funding activity category listed as Education, Health.

What CFDA number is associated with this opportunity?

The CFDA number listed is 93.393.

When was this FOA created?

The listing states the FOA was created on June 22, 2017.

What is the closing date listed in the provided information?

The original closing date shown in the source information is September 7, 2020.

Does the provided listing include an award ceiling or expected number of awards?

No. The provided fields do not include an award ceiling or an expected number of awards.

What does it mean that award ceiling and number of awards are not provided in the listing?

Based on the provided description, it suggests applicants would typically need to consult the full FOA and NIH institute-specific guidance for budget expectations and anticipated funding levels.

What overall research shift is this FOA trying to promote?

It aims to improve how cancer researchers incorporate lived geography over time, treating residential mobility and long-term neighborhood/environmental context as central to understanding cancer risk, survival, and inequities in outcomes.

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