Opportunity Information: Apply for RFA AG 22 023
This NIH opportunity (RFA-AG-22-023) is a limited-competition funding announcement from the National Institute on Aging (NIA) that seeks one cooperative agreement (U24; clinical trial not allowed) to run a Data Management and Coordinating Center (DMCC) for a set of ongoing human longevity translational research projects. The core idea is to create a central hub that helps multiple funded projects work together more efficiently, standardizes and manages the data and resources they generate, and makes those outputs more usable to the broader research community through an expanded and better-supported NIA Exceptional Longevity Portal (the EL Portal).
The DMCC is expected to play an active coordinating role rather than serving as a passive data repository. On the coordination side, it will help integrate research activities across the longevity translational projects, support collaboration among investigators, and generally keep cross-project efforts aligned. On the data side, the DMCC will manage how data and related research resources are deposited into and distributed from the EL Portal, which implies building or enforcing common practices for submission, documentation, organization, and controlled access where appropriate. A major emphasis is on making the collected resources easy for others to discover and analyze, not just storing them.
A defining feature of this FOA is the expectation that the DMCC will also create a collaborative research workspace by leveraging the existing EL Portal infrastructure. The announcement describes this as an interoperable, scalable data commons that combines multidimensional datasets with cloud computing and software tools in a secure environment. In practical terms, the goal is to let authorized users access, deposit, and analyze diverse data types from multiple sources within the same workspace, minimizing barriers caused by data silos, inconsistent formats, or lack of computing capacity. The longer-term purpose is to accelerate translation: turning molecular and other biological factors associated with exceptional health and extended lifespan into insights the field can test, validate, and potentially apply.
Community engagement and outreach are also central expectations. The DMCC is tasked with promoting broader scientific use of the EL Portal by engaging external researchers to analyze the hosted datasets and resources. That typically involves communication and training activities such as documentation, user support, data use guidance, and mechanisms that encourage reuse and secondary analysis, all while maintaining appropriate security, privacy protections, and compliance with NIH policies.
Administratively, this is a discretionary health-related funding opportunity under CFDA 93.866 using a cooperative agreement mechanism, meaning NIH is expected to have substantial programmatic involvement during the project. The original closing date listed is October 28, 2021, and the FOA was created July 22, 2021. Award ceiling and expected number of awards are not specified in the provided text, but the scope suggests a single coordinating center role supporting multiple projects and an existing national portal.
Eligibility is restricted: non-U.S. (foreign) institutions cannot apply, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components as defined by the NIH Grants Policy Statement are allowed, which generally means a U.S.-based applicant organization can include certain foreign collaborations or elements under NIH rules, even though a foreign institution cannot be the applicant organization itself. Eligible applicants also include certain other categories listed, such as eligible agencies of the federal government and U.S. territories or possessions.Apply for RFA AG 22 023
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: Data Management and Coordinating Center (DMCC) and a Collaborative Research Space for Translational Research on Exceptional Longevity (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2021-07-22.
- Applicants must submit their applications by 2021-10-28. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others.
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Frequently Asked Questions (FAQs)
What is this NIH funding opportunity?
This opportunity is NIH RFA-AG-22-023 from the National Institute on Aging (NIA). It is a limited-competition funding announcement to support a single coordinating center that will provide data management and coordination services for ongoing human longevity translational research projects.
What is the award mechanism for this opportunity?
The award mechanism is a cooperative agreement (U24). This means NIH is expected to have substantial programmatic involvement during the project rather than the award operating with minimal NIH interaction.
How many awards does NIA expect to make under this FOA?
The information provided indicates the FOA seeks one cooperative agreement (one U24 award) to run the Data Management and Coordinating Center (DMCC).
Are clinical trials allowed under this opportunity?
No. The opportunity is explicitly described as "clinical trial not allowed."
What is a DMCC in the context of this FOA?
The DMCC is a Data Management and Coordinating Center. In this FOA, it is expected to function as an active coordinating hub that helps multiple funded longevity translational research projects work together efficiently and ensures that data and related research resources are standardized, managed, and shared through NIA's Exceptional Longevity Portal (the EL Portal).
Is the DMCC expected to be a passive data repository?
No. A defining expectation described in the provided text is that the DMCC plays an active coordinating role. It is intended to integrate and align cross-project activities and enable collaboration, not simply store files.
What kinds of coordination activities is the DMCC expected to perform?
Based on the provided description, the DMCC is expected to help integrate research activities across the longevity translational projects, support collaboration among investigators, and keep cross-project efforts aligned to improve efficiency and coordination.
What is the Exceptional Longevity Portal (EL Portal) and how does it relate to this FOA?
The EL Portal is an NIA portal intended to host and make available data and other research resources generated by exceptional longevity research. The DMCC is expected to expand and better support this portal by managing how data and resources are deposited, documented, organized, and distributed so they are easier to discover and analyze by the broader research community.
What data-related responsibilities does the DMCC have for the EL Portal?
The DMCC is expected to manage how data and related research resources are deposited into and distributed from the EL Portal. This implies developing or enforcing common practices for submission, documentation, organization, and (where appropriate) controlled access, with an emphasis on usability and discoverability rather than storage alone.
What is meant by creating a collaborative research workspace through the EL Portal?
The FOA describes leveraging the existing EL Portal infrastructure to create an interoperable, scalable data commons that combines multidimensional datasets with cloud computing and software tools in a secure environment. The practical goal is to let authorized users access, deposit, and analyze diverse data types from multiple sources within one workspace.
Why does the FOA emphasize interoperability and reducing data silos?
The provided text highlights barriers such as data silos, inconsistent formats, and lack of computing capacity. The DMCC is expected to reduce those barriers by standardizing practices and enabling analysis in a shared, secure, cloud-enabled workspace so users can more readily work across datasets from multiple projects.
What is the longer-term scientific purpose of the DMCC and EL Portal improvements?
The longer-term purpose described is to accelerate translation by helping the field turn molecular and other biological factors associated with exceptional health and extended lifespan into insights that can be tested, validated, and potentially applied.
What is expected for community engagement and outreach?
Community engagement is a central expectation. The DMCC is tasked with promoting broader scientific use of the EL Portal by engaging external researchers to analyze hosted datasets and resources, and by supporting communication and training activities such as documentation, user support, data use guidance, and mechanisms that encourage reuse and secondary analysis.
How does the FOA address security, privacy, and compliance?
The description indicates that outreach and broader use should occur while maintaining appropriate security, privacy protections, and compliance with NIH policies. It also references controlled access "where appropriate" for data/resources distributed through the EL Portal.
What agency and program area does this opportunity fall under?
It is a discretionary health-related funding opportunity from the National Institute on Aging (NIA), part of NIH. The CFDA number listed in the provided text is 93.866.
What does "limited competition" mean in this FOA?
The provided information describes the announcement as a limited-competition funding announcement. No additional details about the limitation criteria are included in the provided text beyond the eligibility restrictions noted for applicant organizations.
Who is eligible to apply?
Eligibility is restricted in several ways based on the provided text. Foreign (non-U.S.) institutions cannot apply, and non-domestic components of U.S. organizations are also not eligible to apply. The text also notes that eligible applicants include certain other categories listed, such as eligible agencies of the federal government and U.S. territories or possessions.
Can a foreign institution be the applicant organization?
No. The provided information states that non-U.S. (foreign) institutions cannot apply.
Are non-domestic components of U.S. organizations eligible to apply?
No. The provided information states that non-domestic components of U.S. organizations are not eligible to apply.
Are foreign components allowed at all?
Yes, as described in the provided text: foreign components (as defined by the NIH Grants Policy Statement) are allowed. This generally means a U.S.-based applicant organization may include certain foreign collaborations or elements under NIH rules, even though a foreign institution cannot serve as the applicant organization.
What is the closing date for this FOA?
The original closing date listed in the provided information is October 28, 2021.
When was the FOA created?
The FOA was created on July 22, 2021, based on the provided text.
Is the award ceiling or budget amount provided?
No. The provided information states that the award ceiling is not specified.
Is the expected number of awards specified anywhere in the provided text?
The scope is described as seeking one cooperative agreement (one U24) to run the DMCC, but the provided text also notes that the expected number of awards is not specified. The overall description nonetheless suggests a single coordinating center role.
What kinds of outputs is the DMCC expected to make more usable to the research community?
The provided description focuses on data and related research resources generated by multiple funded longevity translational projects. The DMCC is expected to standardize and manage these outputs, improve documentation and organization, and make them easier to discover and analyze through an expanded and better-supported EL Portal.
What is the relationship between the DMCC and the ongoing translational research projects?
The DMCC is intended to support a set of ongoing human longevity translational research projects by coordinating cross-project activities, enabling collaboration, and providing centralized data management and sharing infrastructure through the EL Portal.
What does it mean that NIH will have "substantial programmatic involvement"?
The provided text explains that the cooperative agreement mechanism implies NIH is expected to have substantial programmatic involvement during the project. No further detail is included in the provided information beyond that general expectation.
Who should use the EL Portal under this FOA's vision?
The FOA emphasizes broader scientific use, including external researchers who can analyze hosted datasets and resources. The DMCC is expected to help enable and encourage this kind of reuse and secondary analysis through engagement, support, and training materials.
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