Opportunity Information: Apply for PA 24 247
The PHS 2024-2 Omnibus Solicitation is a National Institutes of Health (NIH) parent funding opportunity (PA-24-247) that invites eligible U.S. small businesses to apply for Small Business Technology Transfer (STTR) awards using the R41 (Phase I) and R42 (Phase II) grant mechanisms. The purpose is to support early-stage research and development (R and D) projects where a small business works in formal partnership with a research institution, combining commercialization-focused product development with the scientific strengths of the nonprofit or academic research environment. The solicitation is considered an omnibus or parent announcement, meaning it is designed to cover a broad range of NIH-relevant topic areas rather than a single narrowly defined project theme. Applicants are expected to align their proposed work with the missions of the participating NIH awarding components and to select an appropriate topic area referenced in the NIH/CDC/FDA SBIR/STTR Program Descriptions and Research Topics.
This opportunity is specifically labeled “Clinical Trial Not Allowed,” which is a major boundary condition for project design. Applications must not propose clinical trials, and they should be structured around non-clinical research activities such as technology development, feasibility testing, prototyping, assay development, preclinical validation, computational methods, device engineering, or other translational R and D steps that stop short of conducting a clinical trial. In practice, this means the work plan should focus on generating technical proof-of-concept, performance data, and readiness milestones that de-risk the technology and position it for future regulatory, partnering, or follow-on funding pathways, without enrolling human participants into a clinical trial under this award.
Eligibility is centered on U.S. small businesses. Non-domestic (non-U.S.) entities are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply. However, “foreign components,” as defined in the NIH Grants Policy Statement, may be allowable in some cases, which typically refers to discrete project elements performed outside the United States when there is a strong justification that the work cannot be reasonably performed domestically or that a unique resource or expertise is needed. Even when foreign components are permitted, the applicant organization must still be an eligible U.S. small business, and the overall project must remain compliant with NIH policy requirements for justification, oversight, and documentation.
From an administrative and classification standpoint, the opportunity is a discretionary grant program (Funding Instrument Type: Grant) managed by NIH, with an activity scope spanning multiple public purpose areas including health as well as related categories such as education, environment, food and nutrition, and income security/social services, reflecting the breadth of NIH’s participating institutes and centers and the wide set of problem areas that biomedical and behavioral technologies can impact. The solicitation is associated with many CFDA (Assistance Listing) numbers, indicating that multiple NIH components and program areas may use this parent STTR vehicle to support projects. The posting shows an original closing date of 2025-04-05, and it was created on 2024-07-03. While the listing does not provide an award ceiling or expected number of awards in the excerpt provided, STTR awards under R41/R42 are generally milestone-driven, with Phase I commonly used to establish feasibility and Phase II used to continue development toward commercialization readiness, subject to NIH-specific budget caps, program priorities, and review outcomes.
Conceptually, this NOFO is aimed at small businesses that have a credible path to turning R and D into a product, platform, or service that advances NIH mission needs, while leveraging a formal collaboration with a research institution. Competitive applications typically make the public health or scientific need clear, define measurable technical milestones, and describe a realistic commercialization strategy, while also demonstrating that the team has the expertise, facilities, and partnership structure to execute the proposed work. Applicants are expected to ensure their topic choice and scientific aims fit within the NIH component missions identified under the omnibus topics list and to keep the project clearly outside the scope of a clinical trial for this particular parent announcement.Apply for PA 24 247
- The National Institutes of Health in the education, environment, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "PHS 2024-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.172, 93.173, 93.213, 93.233, 93.242, 93.273, 93.279, 93.286, 93.307, 93.350, 93.351, 93.361, 93.393, 93.394, 93.395, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.855, 93.859, 93.865, 93.866, 93.867, 93.879.
- This funding opportunity was created on 2024-07-03.
- Applicants must submit their applications by 2025-04-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
FAQs: PHS 2024-2 Omnibus Solicitation (NIH Parent STTR) PA-24-247
What is the PHS 2024-2 Omnibus Solicitation (PA-24-247)?
It is a National Institutes of Health (NIH) parent funding opportunity that invites eligible U.S. small businesses to apply for Small Business Technology Transfer (STTR) awards. It is described as an "omnibus" or "parent" announcement because it is designed to support a broad range of NIH-relevant research and development (R and D) topics rather than a single narrow theme.
What program and grant mechanisms does this opportunity use?
This opportunity is for the NIH STTR program and uses the R41 (Phase I) and R42 (Phase II) grant mechanisms.
What is the purpose of the STTR awards under this solicitation?
The purpose is to support early-stage R and D where a small business works in a formal partnership with a research institution. The intent is to combine commercialization-focused product development efforts with the scientific strengths and resources typically found in nonprofit or academic research environments.
Who is eligible to apply?
Eligibility is centered on U.S. small businesses. Non-U.S. (non-domestic) entities are not eligible to apply under this opportunity.
Are non-U.S. organizations or non-U.S. subsidiaries eligible?
No. Non-domestic (non-U.S.) entities are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply.
Are any foreign activities allowed at all?
Possibly. "Foreign components," as defined in the NIH Grants Policy Statement, may be allowable in some cases. This generally refers to discrete elements of the project performed outside the United States when there is a strong justification (for example, the work cannot reasonably be performed domestically or requires a unique resource or expertise).
If a foreign component is included, does that make the applicant a foreign entity?
No. Even if a foreign component is permitted, the applicant organization must still be an eligible U.S. small business, and the project must comply with NIH policies on justification, oversight, and documentation for any foreign component work.
Is this opportunity limited to a single research topic area?
No. As an omnibus/parent announcement, it covers a broad range of NIH-relevant topic areas. Applicants are expected to align their proposed work with the missions of participating NIH awarding components.
How do applicants choose the appropriate topic area?
Applicants are expected to select an appropriate topic area referenced in the NIH/CDC/FDA SBIR/STTR Program Descriptions and Research Topics, and ensure the proposed aims align with the mission of the NIH component(s) relevant to that topic.
What does "Clinical Trial Not Allowed" mean for this solicitation?
Applications must not propose clinical trials. The project design must stay outside the scope of conducting a clinical trial, meaning the work plan should not include enrolling human participants into a clinical trial under this award.
What types of work are appropriate if clinical trials are not allowed?
The solicitation anticipates non-clinical research activities such as technology development, feasibility testing, prototyping, assay development, preclinical validation, computational methods, device engineering, and other translational R and D steps that stop short of conducting a clinical trial.
What is the practical goal of the funded work if clinical trials are excluded?
The practical goal is to generate technical proof-of-concept, performance data, and readiness milestones that de-risk the technology and position it for future regulatory steps, partnering discussions, or follow-on funding pathways, without conducting a clinical trial during this award.
What is the funding instrument type?
The funding instrument type is a discretionary grant (Grant).
Which federal agency manages this opportunity?
The opportunity is managed by the National Institutes of Health (NIH).
How broad is the activity scope for this opportunity?
The activity scope spans multiple public purpose areas, including health, and related categories such as education, environment, food and nutrition, and income security/social services. This reflects the breadth of NIH participating institutes and centers and the wide range of problems biomedical and behavioral technologies can impact.
What do the multiple CFDA/Assistance Listing numbers indicate?
The solicitation is associated with many CFDA (Assistance Listing) numbers, indicating that multiple NIH components and program areas may use this parent STTR opportunity to support projects.
What are the key phases of STTR funding mentioned here?
The opportunity references Phase I (R41) and Phase II (R42). Phase I is commonly used to establish feasibility, and Phase II is used to continue development toward commercialization readiness. Progress is generally milestone-driven and subject to NIH-specific policies, program priorities, and review outcomes.
Does the excerpt list an award ceiling or the expected number of awards?
No. The excerpt provided does not include an award ceiling or an expected number of awards.
What are the key dates shown in the listing?
The listing shows it was created on 2024-07-03 and displays an original closing date of 2025-04-05.
What makes an application competitive, based on the description provided?
Competitive applications typically make the public health or scientific need clear, define measurable technical milestones, describe a realistic commercialization strategy, and show that the team has the expertise, facilities, and partnership structure needed to execute the work. They also clearly align with the mission of the relevant NIH component and remain outside the scope of a clinical trial.
What is the core partnership requirement highlighted in the opportunity?
The opportunity emphasizes that the small business should work in formal partnership with a research institution, leveraging the scientific strengths of a nonprofit or academic research environment while focusing on commercialization-oriented product development.
Browse more opportunities from the same category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services
Next opportunity: Africa Regional Democracy Fund
Previous opportunity: D-START: Data Science Track Award for Research Transition (D/START) (R03-Clinical Trial Optional)
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PA 24 247
Applicants also applied for:
Applicants who have applied for this opportunity (PA 24 247) also looked into and applied for these:
| Funding Opportunity |
|---|
| PHS 2024-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed) Apply for PA 24 245 Funding Number: PA 24 245 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2024-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required) Apply for PA 24 246 Funding Number: PA 24 246 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Change of Recipient Organization (Type 7 Parent Clinical Trial Optional) Apply for PA 24 254 Funding Number: PA 24 254 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Research Software Engineer (RSE) Award (R50 Clinical Trials Not Allowed) Apply for RFA OD 24 011 Funding Number: RFA OD 24 011 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Building Sustainable Software Tools for Open Science (R03 Clinical Trial Not Allowed) Apply for RFA OD 24 010 Funding Number: RFA OD 24 010 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 - Independent Clinical Trial Required) Apply for PAR 24 226 Funding Number: PAR 24 226 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Clinical Trial Not Allowed) Apply for PAR 24 225 Funding Number: PAR 24 225 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Knockout Mouse Phenotyping Project Database (UM1) Apply for RFA RM 15 016 Funding Number: RFA RM 15 016 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Knockout Mouse Production and Phenotyping Project (UM1) Apply for RFA RM 15 017 Funding Number: RFA RM 15 017 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Administrative Supplements to Promote Diversity in Research and Development Small Businesses SBIR/STTR (Admin Supp Clinical Trial Not Allowed) Apply for PA 24 255 Funding Number: PA 24 255 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Innovation Corps (I-Corps) at NIH Program for NIH and CDC Translational Research (Admin Supp Clinical Trial NOT Allowed) Apply for PA 25 212 Funding Number: PA 25 212 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Dissemination and Implementation Research in Health (R01 Clinical Trial Optional) Apply for PAR 25 144 Funding Number: PAR 25 144 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed) Apply for PAR 25 134 Funding Number: PAR 25 134 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $375,000 |
| NIH Research Project Grant (Parent R01 Clinical Trial Required) Apply for PA 25 305 Funding Number: PA 25 305 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) Apply for PA 25 301 Funding Number: PA 25 301 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required) Apply for PA 25 303 Funding Number: PA 25 303 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Intervention Research to Improve Native American Health (R01 Clinical Trial Optional) Apply for PAR 25 379 Funding Number: PAR 25 379 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Support for Research Excellence (SuRE) Award (R16 Clinical Trial Not Allowed) Apply for PAR 25 414 Funding Number: PAR 25 414 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $100,000 |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) Apply for PA 25 425 Funding Number: PA 25 425 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) Apply for PA 25 423 Funding Number: PA 25 423 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PA 24 247", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.