Opportunity Information: Apply for SP 21 001
The Strategic Prevention Framework for Prescription Drugs (SPF Rx) is a discretionary grant program from the U.S. Department of Health and Human Services, administered by SAMHSA through its Center for Substance Abuse Prevention (CSAP). Released as a FY 2021 funding opportunity (Opportunity Number SP 21 001; CFDA 93.243), the program is aimed at strengthening statewide and Tribal prevention systems specifically focused on reducing prescription drug misuse, with a strong emphasis on opioids and overdose prevention. The overall intent is to help eligible jurisdictions use a structured prevention planning model to identify drivers of prescription drug misuse, select evidence-based strategies, and coordinate partners across public health, education, and healthcare to reduce harms.
Eligibility is targeted rather than broad. The opportunity is designed for states and U.S. territories (referred to in the notice collectively as "states") and for Tribal entities that have already completed a Strategic Prevention Framework State Incentive Grant (SPF SIG), or that have completed another comparable state-level strategic planning process focused on prescription drug misuse prevention. In other words, this funding is meant to build on an existing foundation of prevention infrastructure and planning capacity, not to start from scratch. The eligible applicant category is listed as "Others (see text field entitled Additional Information on Eligibility for clarification)," but the narrative makes clear that the primary intended applicants are states, territories, and Tribal entities with prior SPF SIG experience or an equivalent planning background in prescription drug misuse prevention.
Programmatically, SPF Rx centers on changing community and system conditions that contribute to misuse, rather than relying only on individual-level messaging. A major theme is raising awareness about the risks and consequences of sharing prescription medications, which is a common pathway into misuse for adolescents and young adults. Alongside public awareness, the program explicitly prioritizes engagement with the pharmaceutical and medical communities, particularly to address the risks of overprescribing to young adults and to promote safer prescribing practices. This means applicants are expected to work collaboratively with prescribers, healthcare systems, and related professional stakeholders, not only with traditional prevention partners.
The grant also emphasizes broad, community-facing prevention education and activities that reach multiple audiences. The description highlights delivering prescription drug abuse prevention efforts to schools and community settings and directly engaging parents, prescribers, and patients. That framing signals an expectation of coordinated, multi-sector outreach where consistent prevention messages and practices reinforce one another across settings where medication decisions are made, medications are stored, and youth and families receive information.
SAMHSA describes success in measurable, outcome-oriented terms. Two indicators are explicitly referenced: reductions in opioid overdoses and the incorporation of Prescription Drug Monitoring Program (PDMP) data into needs assessments and strategic plans. The inclusion of PDMP integration is important because it points to a data-driven approach to prevention planning and monitoring, where jurisdictions are expected to use real-world prescribing and dispensing data to identify hotspots, emerging trends, and priority populations, then reflect that analysis in formal prevention plans and strategy selection.
From an administrative perspective, the opportunity was posted March 1, 2021, with an original application closing date of April 30, 2021. SAMHSA projected 26 awards, and the listed award ceiling is $384,000. The funding instrument is a grant, and the activity category is health. Overall, SPF Rx can be understood as a targeted prevention investment meant to help states, territories, and eligible Tribal entities translate prior prevention planning capacity into focused action on prescription drug misuse, align community education with healthcare practice change, and use PDMP and overdose data to guide strategy and demonstrate impact.Apply for SP 21 001
- The Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis in the health sector is offering a public funding opportunity titled "Strategic Prevention Framework for Prescription Drugs" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.243.
- This funding opportunity was created on Mar 01, 2021.
- Applicants must submit their applications by Apr 30, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $384,000.00 in funding.
- The number of recipients for this funding is limited to 26 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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